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Room temperature phosphorescent materials have many desirable properties, but fine control of these can be challenging. Here, the authors report a strategy for this control by dynamic lanthanide coordination in combination with organic phosphors.
Human glial progenitor cells (hGPCs) lose mitotic competence with age. Here, the authors show that with maturation, adult hGPCs acquire a set of transcriptional repressors that actively suppress developmental gene expression.
This study presents an unprecedented analysis of agricultural land multi-degradation in 40 European countries, using twelve dataset-based processes that were modelled as land degradation convergence and combination pathways across the continent.
Autologous tumor lysate (ATL) dendritic cell (DC) vaccination can induce local and systemic anti-tumor immune responses in malignant glioma patients. In this randomized phase II clinical trial, the authors evaluate the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to ATL-DC vaccination in patients with newly-diagnosed or recurrent WHO Grade III-IV malignant gliomas.
The inherent instability of poly(sulfur) renders the conversion of elementary sulfur into sulfur-rich polymers challenging which limits the use of this industrial by-product. Here, the authors demonstrate that inorganic sulfur can be utilized by copolymerizing with cyclic disulfides, producing high-performance thermoplastic elastomers with self-healing ability and degradability.
To measure temperatures close to absolute zero, authors developed a kind of composite phase diamond (CPD) that can measure temperature at the millikelvin level, making it a promising candidate for next–generation cryogenic temperature sensors.
KtrAB complex is essential in K+ uptake for bacteria. Here authors illustrate the synergism of ATP and Na+ in activating K+ uptake of KtrAB from Bacillus subtilis and its gating mechanism, which may also shed light on other Na+-activated K+ channels.
Primaquine treatment for breastfeeding mothers is currently not recommended. Here, the authors develop a pharmacokinetic model to predict drug exposure of infants and show that ingesting breastmilk from mothers treated with primaquine results in <1% of maternal drug exposure. This suggests that primaquine should not be restricted in post-neonatal breastfeeding women as standard doses are unlikely to cause adverse events in infants.
The authors study a YbCoIn5/CeCoIn5/YbRhIn5 heterostructure. Using non-reciprocity in the second harmonic transport response, they demonstrate the existence of a specific form of finite-momentum pairing called a helical superconducting state, where the phase of the order parameter is spontaneously spatially modulated.
As quantum simulations advance, the ability to measure response functions of simulated systems becomes increasingly important. Here the authors present a linear response framework for computing fermionic and bosonic response functions on a quantum computer, demonstrating advantages over existing methods.
So far, only homoleptic N2 complexes of silicon have been reported under matrix-isolation conditions including but the activation of more inert nitrogen by silylenes remains challenging. Here the authors report on the activation of dinitrogen by silylenes under cryogenic conditions.
Industrial methanol synthesis uses materials based on Cu and ZnO. We present high-resolution imaging of active surfaces which reveals how Zn species are transported at the active Cu interface in diffusion processes controlled by the reactant gas composition.
Dual blockade therapy is currently being trialled for multiple tumour types, but efficacy is variable. Here, the authors use longitudinal proteomics profiling of 22 patients to develop a predictive model of therapy response.
Achieving acoustic waveguides with low loss, tailorability, and easy fabrication is a considerable challenge. Here, the authors introduce suspended anti-resonant acoustic waveguides with superior confinement and high selectivity of acoustic modes, supporting both forward and backward SBS on chip.
Certain devices require rapid adhesion and detachment, but achieving both can be challenging. Here, the authors report the development of a supramolecular hydrogel with reversible tough adhesion and triggered photodetachment.
Developing water compatible synthetic methods for Sulfur(VI) fluoride exchange (SuFEx) chemistry is of paramount importance. Here the authors demonstrate a catalytic dearomative [2+2] photocycloaddition that significantly speeds up the synthesis of heterocyclic alkyl SuFEx hubs, leveraging the unique reactivity at the water-oil interface.
Using computer simulations authors identify the dynamic molecular motions controlling the structural conformation of the TWIK1 ion channel, showing that its ability to transport sodium upon acidification result from the evolution of the classical potassium-selective pore.
The knowledge gained from industrial catalysis benefits advancements of nanocatalytic medicines. Here the authors review the similarities, differences and connections in catalytic reactions between industrial and medical applications to support deep understanding and rational design of nanocatalytic medicines.
The heterochromatic 'condensates' may not be conserved across mammals. This study highlights the influence of host genome on nuclear architecture and challenges the hypothesis that heterochromatin and MeCP2 undergo phase separation.