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For the carbonylation reactions to synthesize aldehyde, ester, amide, and other carbonyl derivatives, a transition metal-free and CO- free reaction was challenging but highly demanded. Here, the authors report a transition metal-free and CO- free method for deoxygenetive/denitrogenetive conversion of phenols and anilines to aldehydes and ketones.
A mitochondrial actin wave fragments mitochondria. Here, the authors find that the wave produces force that is resisted by mitochondrial tethering, inducing fission, with subsequent fusion promoting mitochondrial content mixing and mitochondrial homeostasis.
The cluster miR-17~92 modulates the expression of genes networks and signalling pathways to ensure proper Sry expression timing and subsequent testis differentiation, an unexpected role for miRNAs in the early steps of mammalian sex determination.
FGFR inhibitors (FGFRi) benefit patients with FGFR2-fusion positive intrahepatic cholangiocarcinoma (ICC) but depth and duration of response is often limited. Here, the authors demonstrate that oncogenic FGFR2 signaling promotes a glycolytic phenotype, which is blocked by FGFRi, resulting in a targetable dependence on mitochondrial metabolism.
Ferritin, the cellular iron storage complex, binds NCOA4 and is trafficked to the lysosome for degradation and iron release. Here, authors present the cryo-EM structure of the NCOA4-Ferritin complex with biophysical and cellular characterization.
Common genetic variants can affect an individual’s immune response to pathogens. Here, the authors uncover and characterize variants regulating cytokine responses in Lyme Borreliosis in 1,060 patients.
mRNA therapeutics delivered via lipid nanoparticles are being developed for the treatment of metabolic diseases caused by protein deficiency. Here, the authors use preclinical data to develop translational PK/PD models, which scaled allometrically to humans to predict starting doses for first-in-human clinical studies for in propionic acidemia, methylmalonic acidemia, and phenylketonuria.
Here, the authors demonstrate that mutations in the FG repeats of Nup98 significantly reduce its self-association capabilities and present a cryoEM structure exhibiting higher stability per residue then previously observed, suggesting spatial variations in self-association.
Improving mass transfer through hierarchically porous synthetic materials is a great challenge. Here the authors address this by expanding the original Murray’s law, a biomimetic principle defining the branching of veins in living structures.
Previous studies have reported heterogeneity in the progression to clinical type 1 diabetes in children who develop either insulin- or glutamic acid decarboxylase-specific antibodies as their first autoantibodies. Here, the authors show that children who later develop disease have distinct characteristics in early immune responses, which are dependent on the type of autoantibodies that appear first.
Machine learning has not been strategically applied to design main-group catalysts. Here, the authors built an in-silico library of triarylboranes, which was used to identify reactive catalysts for functionalizing amino acids and peptides with H2.
Metabolic implications in AD are unclear. Here, authors found significant correlations between cognitive impairment and metabolic features in a Chinese aging cohort (n = 1397). The study highlights ammonia disturbance as a potential therapeutic target for AD.
Conventional spectrometers can be bulky and efforts are being made to develop miniaturised versions. Here, the authors present a miniature computational spectrometer based on silver nanoparticles in Fabry-Pérot microcavities for measuring visible spectra.
Polarization reversal dynamics in sliding ferroelectrics is important for the application in slidetronics. Here, the authors observe the interlayer directional sliding induced polarization switching with simultaneous hysteresis response in γ-InSe:Y.
Here, the authors describe an early synziphosurine from the Lower Ordovician Fezouata Shale of Morocco, which exhibits traits that elucidate the long-contentious relationships between crown euchelicerates and their sister taxa, and also clarifies euchelicerate body plan evolution.
In Drosophila, long noncoding RNAs (lncRNAs) are expressed most highly in male germline cells. Here the authors report the subcellular distributions of approximately 600 Drosophila lncRNAs in male reproductive tissues, indicating potential involvement in spermatogenesis, fertility and evolution.
3D printing of functional gradients often requires specialized equipment and costly materials, constraining scalability. Here, using a conventional desktop FDM printer, authors present a 3D printing strategy using a filament that is itself 3D-printed to produce functional gradients.
Transparent roofs offer a solution for harnessing natural light in sustainable buildings. Here, authors demonstrate a polymer-based metamaterial with micro-pyramid surface structures that diffuses sunlight while offering passive cooling and self-cleaning properties.
The end of the green Sahara in the mid-Holocene was gradual, but punctuated by rapidly changing episodes of extreme drought and wetness, to which human societies were exposed and had to adapt to, as a lake record from southern Ethiopia suggests.